GBC46438.1

Protein

Length

546 amino acids

Protein family membership

Methylmalonate-semialdehyde dehydrogenase (IPR010061)

Domains and repeats

Domain
47 - 526
Aldehyde/histidinol dehydrogenase (IPR016161)
Aldehyde dehydrogenase domain (IPR015590)

1 50 100 150 200 250 300 350 400 450 500 546

Detailed signature matches

IPR010061

Methylmalonate-semialdehyde dehydrogenase
1. TIGR01722
  
  54 - 528
  
  TIGRFAMs
  TIGR01722 (TIGR01722)
2. cd07085 (ALDH_F6_MMSDH)
  
  52 - 528
  
  CDD
  cd07085 (ALDH_F6_MMSDH)
IPR016161

Aldehyde/histidinol dehydrogenase
1. SSF53720 (ALDH-like)
  
  47 - 526
  
  SUPERFAMILY
  SSF53720 (ALDH-like)
IPR015590

Aldehyde dehydrogenase domain
1. PF00171 (Aldedh)
  
  61 - 524
  
  Pfam
  PF00171 (Aldedh)
IPR016160

Aldehyde dehydrogenase, cysteine active site
1. PS00070 (ALDEHYDE_D...)
  
  321 - 332
  
  PROSITE patterns
  PS00070 (ALDEHYDE_DEHYDR_CYS)

Residue annotation

tetrameric interfa...

109S

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

111L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

115R

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

118L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

122L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

155Q

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

158E

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

159H

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

168L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

169G

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

170E

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

171Q

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

172L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

173A

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

174V

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

179D

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

182T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

185E

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

278K

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

282K

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

285T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

288G

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

290R

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

464N

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

466G

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

467S

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

469A

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

470R

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

473T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

476I

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

477E

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

479G

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

481I

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

482G

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

483V

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

484N

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

493M

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

497T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

499N

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

513S

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

520Q

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

521T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

522K

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

523T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

524V

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

525T

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

527L

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)

528W

tetrameric interface
109S, 111L, 115R, 118L, 122L, 155Q, 158E, 159H, 168L, 169G, 170E, 171Q, 172L, 173A, 174V, 179D, 182T, 185E, 278K, 282K, 285T, 288G, 290R, 464N, 466G, 467S, 469A, 470R, 473T, 476I, 477E, 479G, 481I, 482G, 483V, 484N, 493M, 497T, 499N, 513S, 520Q, 521T, 522K, 523T, 524V, 525T, 527L, 528W
CDD
cd07085 (ALDH_F6_MMSDH)
NAD binding site c...

194C

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

195P

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

196F

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

197N

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

205W

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

220K

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

223E

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

253V

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

270F

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

271V

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

272G

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

273S

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

276A

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

294N

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

295L

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

296G

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

328C

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

429E

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

431F

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)

457N

NAD binding site
194C, 195P, 196F, 197N, 205W, 220K, 223E, 253V, 270F, 271V, 272G, 273S, 276A, 294N, 295L, 296G, 328C, 429E, 431F, 457N
CDD
cd07085 (ALDH_F6_MMSDH)
catalytic residues...

197N

catalytic residues
197N, 294N, 325G, 328C
CDD
cd07085 (ALDH_F6_MMSDH)

294N

catalytic residues
197N, 294N, 325G, 328C
CDD
cd07085 (ALDH_F6_MMSDH)

325G

catalytic residues
197N, 294N, 325G, 328C
CDD
cd07085 (ALDH_F6_MMSDH)

328C

catalytic residues
197N, 294N, 325G, 328C
CDD
cd07085 (ALDH_F6_MMSDH)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating) activity
GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features