GBC46424.1

Protein

Length

416 amino acids

Protein family membership

Aspartyl/Asparaginyl-tRNA synthetase, class IIb (IPR002312)
- Asparagine-tRNA ligase (IPR004522)

Domains and repeats

Domain
82 - 410
Aminoacyl-tRNA synthetase, class II (IPR006195)
Aminoacyl-tRNA synthetase, class II (D/K/N) (IPR004364)

1 50 100 150 200 250 300 350 416

Detailed signature matches

IPR002312

Aspartyl/Asparaginyl-tRNA synthetase, class IIb
1. PR01042 (TRNASYNTHASP)
  
  161 - 173
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  331 - 347
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  177 - 190
  
  PRINTS
  PR01042 (TRNASYNTHASP)
  
  371 - 385
  
  PRINTS
  PR01042 (TRNASYNTHASP)
IPR004522

Asparagine-tRNA ligase
1. TIGR00457
  
  64 - 416
  
  TIGRFAMs
  TIGR00457 (TIGR00457)
IPR006195

Aminoacyl-tRNA synthetase, class II
1. PS50862 (AA_TRNA_LI...)
  
  102 - 406
  
  PROSITE profiles
  PS50862 (AA_TRNA_LIGASE_II)
IPR004364

Aminoacyl-tRNA synthetase, class II (D/K/N)
1. PF00152 (tRNA-synt_2)
  
  82 - 410
  
  Pfam
  PF00152 (tRNA-synt_2)

no IPR

Unintegrated signatures

SSF55681 (Class II ...)

81 - 409

SUPERFAMILY
SSF55681 (Class II aaRS and biotin synthetases)
cd00776 (AsxRS_core)

79 - 409

CDD
cd00776 (AsxRS_core)

Residue annotation

homodimer interfac...

88I

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

90H

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

94R

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

99S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

105R

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

106N

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

109M

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

113Q

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

120E

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

123Q

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

125H

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

127P

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

128I

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

129I

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

131T

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

142K

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

152Q

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

154F

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

155F

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

156G

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

168H

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

171S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

174S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

175Y

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

176I

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

177P

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

198S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

199E

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

208S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

209F

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

215D

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

372D

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

375K

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

376F

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

377G

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

378S

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)

409R

homodimer interface
88I, 90H, 94R, 99S, 105R, 106N, 109M, 113Q, 120E, 123Q, 125H, 127P, 128I, 129I, 131T, 142K, 152Q, 154F, 155F, 156G, 168H, 171S, 174S, 175Y, 176I, 177P, 198S, 199E, 208S, 209F, 215D, 372D, 375K, 376F, 377G, 378S, 409R
CDD
cd00776 (AsxRS_core)
motif 1 cd00776

127P

motif 1
127P, 128I, 129I, 130T, 131T
CDD
cd00776 (AsxRS_core)

128I

motif 1
127P, 128I, 129I, 130T, 131T
CDD
cd00776 (AsxRS_core)

129I

motif 1
127P, 128I, 129I, 130T, 131T
CDD
cd00776 (AsxRS_core)

130T

motif 1
127P, 128I, 129I, 130T, 131T
CDD
cd00776 (AsxRS_core)

131T

motif 1
127P, 128I, 129I, 130T, 131T
CDD
cd00776 (AsxRS_core)
motif 2 cd00776

186F

motif 2
186F, 187R, 188A, 189E
CDD
cd00776 (AsxRS_core)

187R

motif 2
186F, 187R, 188A, 189E
CDD
cd00776 (AsxRS_core)

188A

motif 2
186F, 187R, 188A, 189E
CDD
cd00776 (AsxRS_core)

189E

motif 2
186F, 187R, 188A, 189E
CDD
cd00776 (AsxRS_core)
active site cd00776

187R

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

189E

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

195K

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

196H

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

339E

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

342G

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

387G

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)

390R

active site
187R, 189E, 195K, 196H, 339E, 342G, 387G, 390R
CDD
cd00776 (AsxRS_core)
motif 3 cd00776

387G

motif 3
387G, 388I, 389E, 390R
CDD
cd00776 (AsxRS_core)

388I

motif 3
387G, 388I, 389E, 390R
CDD
cd00776 (AsxRS_core)

389E

motif 3
387G, 388I, 389E, 390R
CDD
cd00776 (AsxRS_core)

390R

motif 3
387G, 388I, 389E, 390R
CDD
cd00776 (AsxRS_core)

GO term prediction

Biological Process

GO:0006418 tRNA aminoacylation for protein translation
GO:0006421 asparaginyl-tRNA aminoacylation

Molecular Function

GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004816 asparagine-tRNA ligase activity
GO:0005524 ATP binding

Cellular Component

GO:0005737 cytoplasm

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Entry type

Status

Per-residue features