GBC44276.1

Protein

Length

372 amino acids

Protein family membership

UDP-glucose 4-epimerase (IPR005886)

Domains and repeats

Domain
42 - 369
NAD(P)-binding domain (IPR016040)
NAD-dependent epimerase/dehydratase (IPR001509)

1 50 100 150 200 250 300 372

Detailed signature matches

IPR005886

UDP-glucose 4-epimerase
1. cd05247 (UDP_G4E_1_...)
  
  43 - 363
  
  CDD
  cd05247 (UDP_G4E_1_SDR_e)
2. TIGR01179
  
  43 - 367
  
  TIGRFAMs
  TIGR01179 (TIGR01179)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  42 - 369
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR001509

NAD-dependent epimerase/dehydratase
1. PF01370 (Epimerase)
  
  44 - 294
  
  Pfam
  PF01370 (Epimerase)

Residue annotation

NAD binding site c...

48G

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

50A

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

51G

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

52Y

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

53I

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

73D

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

74N

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

75L

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

76S

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

77K

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

78G

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

92A

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

93D

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

94I

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

115F

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

116C

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

117A

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

119I

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

134N

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

157S

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

158S

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

159T

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

183Y

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

187K

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

210Y

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

211F

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)

213A

NAD binding site
48G, 50A, 51G, 52Y, 53I, 73D, 74N, 75L, 76S, 77K, 78G, 92A, 93D, 94I, 115F, 116C, 117A, 119I, 134N, 157S, 158S, 159T, 183Y, 187K, 210Y, 211F, 213A
CDD
cd05247 (UDP_G4E_1_SDR_e)
homodimer interfac...

125V

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

127D

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

128P

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

129L

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

132Y

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

133E

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

136V

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

137T

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

140I

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

141Y

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

143L

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

144Q

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

147Q

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

182P

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

185D

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

189T

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

192K

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

193I

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

195G

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

196W

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)

197C

homodimer interface
125V, 127D, 128P, 129L, 132Y, 133E, 136V, 137T, 140I, 141Y, 143L, 144Q, 147Q, 182P, 185D, 189T, 192K, 193I, 195G, 196W, 197C
CDD
cd05247 (UDP_G4E_1_SDR_e)
active site cd05247

135N

active site
135N, 159T, 183Y, 187K
CDD
cd05247 (UDP_G4E_1_SDR_e)

159T

active site
135N, 159T, 183Y, 187K
CDD
cd05247 (UDP_G4E_1_SDR_e)

183Y

active site
135N, 159T, 183Y, 187K
CDD
cd05247 (UDP_G4E_1_SDR_e)

187K

active site
135N, 159T, 183Y, 187K
CDD
cd05247 (UDP_G4E_1_SDR_e)
substrate binding ...

159T

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

160A

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

161A

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

183Y

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

210Y

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

211F

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

212N

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

230T

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

231H

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

232L

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

247I

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

248K

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

249I

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

250Y

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

261C

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

263R

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

265Y

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

301V

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

324R

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

327D

substrate binding site
159T, 160A, 161A, 183Y, 210Y, 211F, 212N, 230T, 231H, 232L, 247I, 248K, 249I, 250Y, 261C, 263R, 265Y, 301V, 324R, 327D
CDD
cd05247 (UDP_G4E_1_SDR_e)

GO term prediction

Biological Process

GO:0006012 galactose metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0003978 UDP-glucose 4-epimerase activity
GO:0050662 coenzyme binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features