GBC43817.1

Protein

Length

3,317 amino acids

Protein family membership

Serine/threonine-protein kinase SMG1 (IPR031559)

Domains and repeats

Domain
1 - 155
PIK-related kinase (IPR014009)
1,294 - 1,502
PIK-related kinase, FAT (IPR003151)
Domain
27 - 283
Armadillo-type fold (IPR016024)
1,813 - 2,228
Protein kinase-like domain (IPR011009)
Phosphatidylinositol 3-/4-kinase, catalytic domain (IPR000403)
3,285 - 3,317
FATC domain (IPR003152)

1 500 1000 1500 2000 2500 3000 3317

Detailed signature matches

IPR031559

Serine/threonine-protein kinase SMG1
1. PF15785 (SMG1)
  
  748 - 1,113
  
  Pfam
  PF15785 (SMG1)
IPR014009

PIK-related kinase
1. PS51189 (FAT)
  
  1 - 155
  
  PROSITE profiles
  PS51189 (FAT)
IPR016024

Armadillo-type fold
1. SSF48371 (ARM repeat)
  
  27 - 283
  
  SUPERFAMILY
  SSF48371 (ARM repeat)
IPR003151

PIK-related kinase, FAT
1. PF02259 (FAT)
  
  1,294 - 1,502
  
  Pfam
  PF02259 (FAT)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  2,037 - 2,189
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
  
  1,813 - 1,976
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000403

Phosphatidylinositol 3-/4-kinase, catalytic domain
1. SM00146 (pi3k_hr1_6)
  
  1,900 - 2,228
  
  SMART
  SM00146 (pi3k_hr1_6)
2. PF00454 (PI3_PI4_ki...)
  
  1,898 - 2,172
  
  Pfam
  PF00454 (PI3_PI4_kinase)
3. PS50290 (PI3_4_KINA...)
  
  1,899 - 2,220
  
  PROSITE profiles
  PS50290 (PI3_4_KINASE_3)
IPR003152

FATC domain
1. SM01343 (FATC_2)
  
  3,285 - 3,317
  
  SMART
  SM01343 (FATC_2)
2. PF02260 (FATC)
  
  3,287 - 3,317
  
  Pfam
  PF02260 (FATC)
3. PS51190 (FATC)
  
  3,285 - 3,317
  
  PROSITE profiles
  PS51190 (FATC)
IPR018936

Phosphatidylinositol 3/4-kinase, conserved site
1. PS00916 (PI3_4_KINA...)
  
  2,066 - 2,086
  
  PROSITE patterns
  PS00916 (PI3_4_KINASE_2)

no IPR

Unintegrated signatures

Coil

1,732 - 1,752

COILS
Coil (Coil)

3,317 - 3,317

COILS
Coil (Coil)

2,176 - 2,196

COILS
Coil (Coil)
SM01345 (Rapamycin_...)

1,705 - 1,832

SMART
SM01345 (Rapamycin_bind_3)
cd05170 (PIKKc_SMG1)

1,870 - 2,171

CDD
cd05170 (PIKKc_SMG1)
mobidb-lite (disord...)

2,229 - 2,251

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

ATP binding site c...

1,880L

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,882T

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,883K

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,884T

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,886P

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,902L

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,904K

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,907E

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,942Y

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,954I

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,955Q

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,956W

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,957V

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

1,962C

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

2,086N

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

2,088L

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

2,099I

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)

2,100D

ATP binding site
1,880L, 1,882T, 1,883K, 1,884T, 1,886P, 1,902L, 1,904K, 1,907E, 1,942Y, 1,954I, 1,955Q, 1,956W, 1,957V, 1,962C, 2,086N, 2,088L, 2,099I, 2,100D
CDD
cd05170 (PIKKc_SMG1)
catalytic loop cd0...

2,078G

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,079L

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,080G

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,081D

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,082R

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,083H

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,084L

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,085D

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)

2,086N

catalytic loop
2,078G, 2,079L, 2,080G, 2,081D, 2,082R, 2,083H, 2,084L, 2,085D, 2,086N
CDD
cd05170 (PIKKc_SMG1)
activation loop (A...

2,100D

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,101Y

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,102N

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,103V

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,104C

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,105F

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,106E

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,107K

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,108G

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,109K

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,110K

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,111L

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,112R

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,113V

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,114P

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,115E

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,116T

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,117I

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,118P

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,119F

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,120R

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,121L

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

2,122T

activation loop (A-loop)
2,100D, 2,101Y, 2,102N, 2,103V, 2,104C, 2,105F, 2,106E, 2,107K, 2,108G, 2,109K, 2,110K, 2,111L, 2,112R, 2,113V, 2,114P, 2,115E, 2,116T, 2,117I, 2,118P, 2,119F, 2,120R, 2,121L, 2,122T
CDD
cd05170 (PIKKc_SMG1)

GO term prediction

Biological Process

GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0016310 phosphorylation

Molecular Function

GO:0004674 protein serine/threonine kinase activity
GO:0005488 binding
GO:0005515 protein binding
GO:0016301 kinase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features