GBC42795.1

Protein

Length

215 amino acids

Protein family membership

Proteasome, subunit alpha/beta (IPR001353)
- Proteasome B-type subunit (IPR023333)
  - Peptidase T1A, proteasome beta-subunit (IPR000243)

Domains and repeats

Domain
7 - 198
Nucleophile aminohydrolases, N-terminal (IPR029055)

1 20 40 60 80 100 120 140 160 180 200 215

Detailed signature matches

IPR001353

Proteasome, subunit alpha/beta
1. PF00227 (Proteasome)
  
  8 - 190
  
  Pfam
  PF00227 (Proteasome)
IPR023333

Proteasome B-type subunit
1. PS51476 (PROTEASOME...)
  
  11 - 190
  
  PROSITE profiles
  PS51476 (PROTEASOME_BETA_2)
IPR000243

Peptidase T1A, proteasome beta-subunit
1. PR00141 (PROTEASOME)
  
  151 - 162
  
  PRINTS
  PR00141 (PROTEASOME)
  
  176 - 187
  
  PRINTS
  PR00141 (PROTEASOME)
  
  140 - 151
  
  PRINTS
  PR00141 (PROTEASOME)
  
  19 - 34
  
  PRINTS
  PR00141 (PROTEASOME)
IPR029055

Nucleophile aminohydrolases, N-terminal
1. SSF56235 (N-termina...)
  
  7 - 198
  
  SUPERFAMILY
  SSF56235 (N-terminal nucleophile aminohydrolases (Ntn hydrolases))
IPR016050

Proteasome beta-type subunit, conserved site
1. PS00854 (PROTEASOME...)
  
  15 - 62
  
  PROSITE patterns
  PS00854 (PROTEASOME_BETA_1)

no IPR

Unintegrated signatures

cd03762 (proteasome...)

12 - 199

CDD
cd03762 (proteasome_beta_type_6)

Residue annotation

active site cd03762

12T

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

28D

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

30R

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

44K

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

141S

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

178D

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

181S

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)

182G

active site
12T, 28D, 30R, 44K, 141S, 178D, 181S, 182G
CDD
cd03762 (proteasome_beta_type_6)
beta subunit inter...

30R

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

33T

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

35A

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

36Y

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

37I

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

38A

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

39N

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

40R

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

60A

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

62D

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

77F

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

89S

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

92A

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

93L

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

95Q

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

96E

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

99Y

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

102K

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

126P

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

128G

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

130S

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

131L

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

132H

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

133K

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

136F

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

144T

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

145Y

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

147Y

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

148G

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

151D

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

152T

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

153A

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

169T

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

176S

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

177R

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

178D

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

179G

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

182G

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

183G

beta subunit interaction site
30R, 33T, 35A, 36Y, 37I, 38A, 39N, 40R, 60A, 62D, 77F, 89S, 92A, 93L, 95Q, 96E, 99Y, 102K, 126P, 128G, 130S, 131L, 132H, 133K, 136F, 144T, 145Y, 147Y, 148G, 151D, 152T, 153A, 169T, 176S, 177R, 178D, 179G, 182G, 183G
CDD
cd03762 (proteasome_beta_type_6)

GO term prediction

Biological Process

GO:0051603 proteolysis involved in cellular protein catabolic process

Molecular Function

GO:0004175 endopeptidase activity
GO:0004298 threonine-type endopeptidase activity

Cellular Component

GO:0005839 proteasome core complex

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Entry type

Status

Per-residue features