GBC42412.1

Protein

Length

284 amino acids

Protein family membership

Diphthine synthase (IPR004551)

Domains and repeats

Domain
1 - 266
Tetrapyrrole methylase (IPR000878)

1 50 100 150 200 250 284

Detailed signature matches

IPR004551

Diphthine synthase
1. MF_01084 (Diphthine...)
  
  1 - 270
  
  HAMAP
  MF_01084 (Diphthine_synth)
2. PIRSF036432 (Diphth...)
  
  1 - 274
  
  PIRSF
  PIRSF036432 (Diphthine_synth)
3. TIGR00522
  
  1 - 270
  
  TIGRFAMs
  TIGR00522 (TIGR00522)
4. cd11647 (Diphthine_...)
  
  1 - 255
  
  CDD
  cd11647 (Diphthine_synthase)
IPR000878

Tetrapyrrole methylase
1. SSF53790 (Tetrapyrr...)
  
  1 - 266
  
  SUPERFAMILY
  SSF53790 (Tetrapyrrole methylase)
2. PF00590 (TP_methylase)
  
  1 - 235
  
  Pfam
  PF00590 (TP_methylase)

Residue annotation

homodimer interfac...

9L

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

11D

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

13K

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

14D

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

15I

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

16T

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

17I

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

18K

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

20L

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

21E

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

86F

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

87G

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

92A

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

95I

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

96I

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

99K

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

100E

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

106Q

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

107T

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

108I

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

109H

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

110N

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

111A

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

112S

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

114M

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

115N

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

116A

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

118G

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

119A

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

124L

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

125Y

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

127F

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

128G

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

129Q

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

130T

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

151E

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

155L

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

157L

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

222G

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)

225T

homodimer interface
9L, 11D, 13K, 14D, 15I, 16T, 17I, 18K, 20L, 21E, 86F, 87G, 92A, 95I, 96I, 99K, 100E, 106Q, 107T, 108I, 109H, 110N, 111A, 112S, 114M, 115N, 116A, 118G, 119A, 124L, 125Y, 127F, 128G, 129Q, 130T, 151E, 155L, 157L, 222G, 225T
CDD
cd11647 (Diphthine_synthase)
SAM binding site c...

9L

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

35T

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

83G

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

84D

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

87G

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

88A

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

89T

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

112S

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

113I

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

162L

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

163L

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

218I

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

220R

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

221L

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

246L

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

247H

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

248S

SAM binding site
9L, 35T, 83G, 84D, 87G, 88A, 89T, 112S, 113I, 162L, 163L, 218I, 220R, 221L, 246L, 247H, 248S
CDD
cd11647 (Diphthine_synthase)

GO term prediction

Biological Process

GO:0008152 metabolic process
GO:0017183 peptidyl-diphthamide biosynthetic process from peptidyl-histidine

Molecular Function

GO:0004164 diphthine synthase activity
GO:0008168 methyltransferase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features