GBC39607.1

Protein

Length

351 amino acids

Protein family membership

Mitogen-activated protein (MAP) kinase, p38 (IPR008352)

Domains and repeats

Domain
10 - 314
Protein kinase-like domain (IPR011009)
Protein kinase domain (IPR000719)

1 50 100 150 200 250 300 351

Detailed signature matches

IPR008352

Mitogen-activated protein (MAP) kinase, p38
1. PR01773 (P38MAPKINASE)
  
  304 - 314
  
  PRINTS
  PR01773 (P38MAPKINASE)
  
  267 - 280
  
  PRINTS
  PR01773 (P38MAPKINASE)
IPR011009

Protein kinase-like domain
1. SSF56112 (Protein k...)
  
  10 - 314
  
  SUPERFAMILY
  SSF56112 (Protein kinase-like (PK-like))
IPR000719

Protein kinase domain
1. SM00220 (serkin_6)
  
  17 - 305
  
  SMART
  SM00220 (serkin_6)
2. PS50011 (PROTEIN_KI...)
  
  17 - 305
  
  PROSITE profiles
  PS50011 (PROTEIN_KINASE_DOM)
3. PF00069 (Pkinase)
  
  17 - 305
  
  Pfam
  PF00069 (Pkinase)
IPR017441

Protein kinase, ATP binding site
1. PS00107 (PROTEIN_KI...)
  
  23 - 47
  
  PROSITE patterns
  PS00107 (PROTEIN_KINASE_ATP)
IPR003527

Mitogen-activated protein (MAP) kinase, conserved site
1. PS01351 (MAPK)
  
  51 - 153
  
  PROSITE patterns
  PS01351 (MAPK)
IPR008271

Serine/threonine-protein kinase, active site
1. PS00108 (PROTEIN_KI...)
  
  137 - 149
  
  PROSITE patterns
  PS00108 (PROTEIN_KINASE_ST)

no IPR

Unintegrated signatures

cd07849 (STKc_ERK1_...)

11 - 349

CDD
cd07849 (STKc_ERK1_2_like)

Residue annotation

ATP binding site c...

23V

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

24G

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

25E

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

26G

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

28Y

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

29G

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

31V

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

44A

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

46K

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

76I

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

97Q

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

98E

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

99L

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

100M

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

103D

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

106R

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

145S

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

146N

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

148L

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

158C

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)

159D

ATP binding site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 76I, 97Q, 98E, 99L, 100M, 103D, 106R, 145S, 146N, 148L, 158C, 159D
CDD
cd07849 (STKc_ERK1_2_like)
active site cd07849

23V

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

24G

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

25E

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

26G

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

28Y

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

29G

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

31V

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

44A

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

46K

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

62R

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

76I

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

97Q

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

98E

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

99L

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

100M

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

103D

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

105H

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

106R

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

141D

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

143K

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

145S

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

146N

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

148L

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

158C

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

159D

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

162L

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

177T

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

179Y

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

180V

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

181A

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

182T

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

184W

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

222G

active site
23V, 24G, 25E, 26G, 28Y, 29G, 31V, 44A, 46K, 62R, 76I, 97Q, 98E, 99L, 100M, 103D, 105H, 106R, 141D, 143K, 145S, 146N, 148L, 158C, 159D, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)
polypeptide substr...

62R

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

105H

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

141D

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

143K

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

162L

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

177T

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

179Y

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

180V

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

181A

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

182T

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

184W

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)

222G

polypeptide substrate binding site
62R, 105H, 141D, 143K, 162L, 177T, 179Y, 180V, 181A, 182T, 184W, 222G
CDD
cd07849 (STKc_ERK1_2_like)
KIM docking site c...

73E

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

101E

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

102T

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

106R

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

107V

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

110T

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

111Q

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

116D

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

117H

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

120Y

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

123Y

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

127R

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

149L

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

150N

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

151A

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

152N

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

153C

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

154D

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

308Y

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

310D

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)

313D

KIM docking site
73E, 101E, 102T, 106R, 107V, 110T, 111Q, 116D, 117H, 120Y, 123Y, 127R, 149L, 150N, 151A, 152N, 153C, 154D, 308Y, 310D, 313D
CDD
cd07849 (STKc_ERK1_2_like)
activation loop (A...

158C

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

159D

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

160F

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

161G

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

162L

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

163A

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

164R

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

165S

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

166A

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

167N

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

168S

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

169S

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

170D

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

171E

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

172H

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

173S

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

174G

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

175F

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

176M

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

177T

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

178E

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

179Y

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

180V

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

181A

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

182T

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

183R

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

184W

activation loop (A-loop)
158C, 159D, 160F, 161G, 162L, 163A, 164R, 165S, 166A, 167N, 168S, 169S, 170D, 171E, 172H, 173S, 174G, 175F, 176M, 177T, 178E, 179Y, 180V, 181A, 182T, 183R, 184W
CDD
cd07849 (STKc_ERK1_2_like)

GO term prediction

Biological Process

GO:0006468 protein phosphorylation

Molecular Function

GO:0004672 protein kinase activity
GO:0004707 MAP kinase activity
GO:0005524 ATP binding

Cellular Component

None predicted.

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Entry type

Status

Per-residue features