Protein

GBC37840.1

Length
946 amino acids

Protein family membership

Domains and repeats

  1. Domain
1 100 200 300 400 500 600 700 800 946

Detailed signature matches

  1. Family IPR000672
    Tetrahydrofolate dehydrogenase/cyclohydrolase
    1. PR00085 (THFDHDRGNASE)
    2. MF_01576 (THF_DHG_CYH)
  2. Family IPR000559
    Formate-tetrahydrofolate ligase, FTHFS
    1. cd00477 (FTHFS)
    2. MF_01543 (FTHFS)
    3. PF01268 (FTHFS)
  3. Domain IPR020630
    Tetrahydrofolate dehydrogenase/cyclohydrolase, catalytic domain
    1. PF00763 (THF_DHG_CYH)
  4. Domain IPR016040
    NAD(P)-binding domain
    1. SSF51735 (NAD(P)-bi...)
  5. Domain IPR020631
    Tetrahydrofolate dehydrogenase/cyclohydrolase, NAD(P)-binding domain
    1. PF02882 (THF_DHG_CYH_C)
  6. Domain IPR027417
    P-loop containing nucleoside triphosphate hydrolase
    1. SSF52540 (P-loop co...)
  7. SITE IPR020867
    Tetrahydrofolate dehydrogenase/cyclohydrolase, conserved site
    1. PS00767 (THF_DHG_CYH_2)
    2. PS00766 (THF_DHG_CYH_1)
  8. SITE IPR020628
    Formate-tetrahydrofolate ligase, FTHFS, conserved site
    1. PS00722 (FTHFS_2)
    2. PS00721 (FTHFS_1)
Unintegrated signatures no IPR
Unintegrated signatures
  1. Coil
  2. SSF53223 (Aminoacid...)
  3. cd01080 (NAD_bind_m...)

Residue annotation

  1. homodimer interfac...
  2. NADP binding site ...
  3. substrate binding ...
  4. Cesium cation bind...
  5. Potassium binding ...

GO term prediction

Biological Process

GO:0009396 folic acid-containing compound biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0004329 formate-tetrahydrofolate ligase activity
GO:0004488 methylenetetrahydrofolate dehydrogenase (NADP+) activity
GO:0005524 ATP binding

Cellular Component

None predicted.