GBC36131.1

Protein

Length

493 amino acids

Protein family membership

Fumarate lyase family (IPR000362)
- Fumarate hydratase, class II (IPR005677)

Domains and repeats

Domain
33 - 490
L-Aspartase-like (IPR008948)
Domain
41 - 372
Fumarate lyase, N-terminal (IPR022761)
438 - 490
Fumarase C, C-terminal (IPR018951)

1 50 100 150 200 250 300 350 400 450 493

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  210 - 228
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  347 - 363
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  301 - 328
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  164 - 182
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR005677

Fumarate hydratase, class II
1. TIGR00979
  
  33 - 491
  
  TIGRFAMs
  TIGR00979 (TIGR00979)
2. MF_00743 (FumaraseC)
  
  33 - 492
  
  HAMAP
  MF_00743 (FumaraseC)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  33 - 490
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  41 - 372
  
  Pfam
  PF00206 (Lyase_1)
IPR018951

Fumarase C, C-terminal
1. PF10415 (FumaraseC_C)
  
  438 - 490
  
  Pfam
  PF10415 (FumaraseC_C)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  347 - 356
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

cd01362 (Fumarase_c...)

34 - 489

CDD
cd01362 (Fumarase_classII)

Residue annotation

active site cd01362

128S

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

130T

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

156S

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

159H

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

160P

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

161N

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

162D

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

169S

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

170S

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

171N

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

218H

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

354K

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

356N

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)

361E

active site
128S, 130T, 156S, 159H, 160P, 161N, 162D, 169S, 170S, 171N, 218H, 354K, 356N, 361E
CDD
cd01362 (Fumarase_classII)
tetramer interface...

216R

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

217T

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

218H

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

219L

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

223T

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

229D

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

230E

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

236Q

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

240F

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

244R

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

262V

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

292P

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

293N

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

296E

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

299A

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

300S

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

302D

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

305V

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

306E

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

309G

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

312N

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

313T

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

316V

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

317S

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

319M

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

320K

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

323N

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

324D

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

374H

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

382S

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

385H

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

386F

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

387E

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

440T

tetramer interface
216R, 217T, 218H, 219L, 223T, 229D, 230E, 236Q, 240F, 244R, 262V, 292P, 293N, 296E, 299A, 300S, 302D, 305V, 306E, 309G, 312N, 313T, 316V, 317S, 319M, 320K, 323N, 324D, 374H, 382S, 385H, 386F, 387E, 440T
CDD
cd01362 (Fumarase_classII)

GO term prediction

Biological Process

GO:0006099 tricarboxylic acid cycle
GO:0006106 fumarate metabolic process

Molecular Function

GO:0003824 catalytic activity
GO:0004333 fumarate hydratase activity
GO:0016829 lyase activity

Cellular Component

GO:0045239 tricarboxylic acid cycle enzyme complex

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Entry type

Status

Per-residue features