GBC35348.1

Protein

Length

1,315 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
8 - 163
NAD(P)-binding domain (IPR016040)
Sirohaem synthase, N-terminal (IPR006367)
284 - 463
Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal (IPR002880)
498 - 632
Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II (IPR009014)
650 - 813
Pyruvate-flavodoxin oxidoreductase, central domain (IPR002869)
953 - 963
Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709)
1,085 - 1,092
Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709)
1,154 - 1,258
Oxidoreductase FAD/NAD(P)-binding (IPR001433)
Flavoprotein pyridine nucleotide cytochrome reductase (IPR001709)
Domain
133 - 156
Siroheme synthase, central domain (IPR028281)
269 - 467
Thiamin diphosphate-binding fold (IPR029061)
676 - 818
Pyruvate/ketoisovalerate oxidoreductase, catalytic domain (IPR019752)
910 - 1,147
Riboflavin synthase-like beta-barrel (IPR017938)
Ferredoxin reductase-type FAD-binding domain (IPR017927)
FAD-binding, type 1 (IPR003097)

1 200 400 600 800 1000 1200 1315

Detailed signature matches

IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  8 - 126
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR006367

Sirohaem synthase, N-terminal
1. TIGR01470
  
  11 - 163
  
  TIGRFAMs
  TIGR01470 (TIGR01470)
2. PF13241 (NAD_binding_7)
  
  12 - 126
  
  Pfam
  PF13241 (NAD_binding_7)
IPR028281

Siroheme synthase, central domain
1. PF14824 (Sirohm_syn...)
  
  133 - 156
  
  Pfam
  PF14824 (Sirohm_synth_M)
IPR029061

Thiamin diphosphate-binding fold
1. SSF52518 (Thiamin d...)
  
  269 - 467
  
  SUPERFAMILY
  SSF52518 (Thiamin diphosphate-binding fold (THDP-binding))
IPR002880

Pyruvate flavodoxin/ferredoxin oxidoreductase, N-terminal
1. PF01855 (POR_N)
  
  284 - 463
  
  Pfam
  PF01855 (POR_N)
IPR009014

Transketolase C-terminal/Pyruvate-ferredoxin oxidoreductase domain II
1. SSF52922 (TK C-term...)
  
  498 - 632
  
  SUPERFAMILY
  SSF52922 (TK C-terminal domain-like)
IPR002869

Pyruvate-flavodoxin oxidoreductase, central domain
1. SSF53323 (Pyruvate-...)
  
  650 - 813
  
  SUPERFAMILY
  SSF53323 (Pyruvate-ferredoxin oxidoreductase, PFOR, domain III)
IPR019752

Pyruvate/ketoisovalerate oxidoreductase, catalytic domain
1. PF01558 (POR)
  
  676 - 818
  
  Pfam
  PF01558 (POR)
IPR017938

Riboflavin synthase-like beta-barrel
1. SSF63380 (Riboflavi...)
  
  910 - 1,141
  
  SUPERFAMILY
  SSF63380 (Riboflavin synthase domain-like)
IPR017927

Ferredoxin reductase-type FAD-binding domain
1. PS51384 (FAD_FR)
  
  917 - 1,147
  
  PROSITE profiles
  PS51384 (FAD_FR)
IPR003097

FAD-binding, type 1
1. PF00667 (FAD_binding_1)
  
  913 - 1,124
  
  Pfam
  PF00667 (FAD_binding_1)
IPR001433

Oxidoreductase FAD/NAD(P)-binding
1. PF00175 (NAD_binding_1)
  
  1,157 - 1,258
  
  Pfam
  PF00175 (NAD_binding_1)
IPR001709

Flavoprotein pyridine nucleotide cytochrome reductase
1. PR00371 (FPNCR)
  
  953 - 963
  
  PRINTS
  PR00371 (FPNCR)
  
  1,227 - 1,243
  
  PRINTS
  PR00371 (FPNCR)
  
  1,183 - 1,192
  
  PRINTS
  PR00371 (FPNCR)
  
  1,196 - 1,207
  
  PRINTS
  PR00371 (FPNCR)
  
  1,085 - 1,092
  
  PRINTS
  PR00371 (FPNCR)
  
  1,154 - 1,173
  
  PRINTS
  PR00371 (FPNCR)

no IPR

Unintegrated signatures

SSF52343 (Ferredoxi...)

1,143 - 1,285

SUPERFAMILY
SSF52343 (Ferredoxin reductase-like, C-terminal NADP-linked domain)
SSF75615 (Siroheme ...)

121 - 209

SUPERFAMILY
SSF75615 (Siroheme synthase middle domains-like)
cd06207 (CyPoR_like)

923 - 1,283

CDD
cd06207 (CyPoR_like)

Residue annotation

FAD binding pocket...

958A

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,085R

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,086H

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,087Y

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,088S

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,103L

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,105V

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,119G

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,120Q

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,121C

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)

1,122T

FAD binding pocket
958A, 1,085R, 1,086H, 1,087Y, 1,088S, 1,103L, 1,105V, 1,119G, 1,120Q, 1,121C, 1,122T
CDD
cd06207 (CyPoR_like)
FAD binding motif ...

1,085R

FAD binding motif
1,085R, 1,087Y, 1,088S
CDD
cd06207 (CyPoR_like)

1,087Y

FAD binding motif
1,085R, 1,087Y, 1,088S
CDD
cd06207 (CyPoR_like)

1,088S

FAD binding motif
1,085R, 1,087Y, 1,088S
CDD
cd06207 (CyPoR_like)
catalytic residues...

1,088S

catalytic residues
1,088S, 1,255C
CDD
cd06207 (CyPoR_like)

1,255C

catalytic residues
1,088S, 1,255C
CDD
cd06207 (CyPoR_like)
NAD binding pocket...

1,105V

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,106T

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,107V

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,108E

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,158L

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,160T

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,191S

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,192R

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,221S

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,222R

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,229Y

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,231Q

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)

1,261V

NAD binding pocket
1,105V, 1,106T, 1,107V, 1,108E, 1,158L, 1,160T, 1,191S, 1,192R, 1,221S, 1,222R, 1,229Y, 1,231Q, 1,261V
CDD
cd06207 (CyPoR_like)
phosphate binding ...

1,119G

phosphate binding motif
1,119G, 1,122T, 1,125L
CDD
cd06207 (CyPoR_like)

1,122T

phosphate binding motif
1,119G, 1,122T, 1,125L
CDD
cd06207 (CyPoR_like)

1,125L

phosphate binding motif
1,119G, 1,122T, 1,125L
CDD
cd06207 (CyPoR_like)
beta-alpha-beta st...

1,155M

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

1,159G

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

1,160T

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

1,161G

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

1,162M

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

1,164P

beta-alpha-beta structure motif
1,155M, 1,159G, 1,160T, 1,161G, 1,162M, 1,164P
CDD
cd06207 (CyPoR_like)

GO term prediction

Biological Process

GO:0006779 porphyrin-containing compound biosynthetic process
GO:0008152 metabolic process
GO:0019354 siroheme biosynthetic process
GO:0055114 oxidation-reduction process

Molecular Function

GO:0003824 catalytic activity
GO:0016491 oxidoreductase activity
GO:0016903 oxidoreductase activity, acting on the aldehyde or oxo group of donors
GO:0043115 precorrin-2 dehydrogenase activity

Cellular Component