GBC27599.1

Protein

Length

1,571 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
329 - 428
Retrotransposon gag domain (IPR005162)
740 - 839
Aspartic peptidase domain (IPR021109)
1,178 - 1,357
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1400 1571

Detailed signature matches

IPR005162

Retrotransposon gag domain
1. PF03732 (Retrotrans...)
  
  329 - 428
  
  Pfam
  PF03732 (Retrotrans_gag)
IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  740 - 839
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,197 - 1,356
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,178 - 1,357
  
  PROSITE profiles
  PS50878 (RT_POL)

no IPR

Unintegrated signatures

Coil

868 - 902

COILS
Coil (Coil)
PF13650 (Asp_protea...)

743 - 830

Pfam
PF13650 (Asp_protease_2)
SSF56672 (DNA/RNA p...)

1,122 - 1,556

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

745 - 831

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

1,183 - 1,357

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,451 - 1,570

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

868 - 901

MobiDB Lite
mobidb-lite (disorder_prediction)

498 - 527

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

756D

Catalytic residue
756D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

756D

catalytic motif
756D, 757S, 758G
CDD
cd00303 (retropepsin_like)

757S

catalytic motif
756D, 757S, 758G
CDD
cd00303 (retropepsin_like)

758G

catalytic motif
756D, 757S, 758G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

756D

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

758G

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

760A

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

784M

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

785I

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

786N

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)

825I

inhibitor binding site
756D, 758G, 760A, 784M, 785I, 786N, 825I
CDD
cd00303 (retropepsin_like)
Active site flap c...

784M

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

785I

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

786N

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

787V

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

791R

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

792K

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

793R

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)

794P

Active site flap
784M, 785I, 786N, 787V, 791R, 792K, 793R, 794P
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,244D

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,245L

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,246A

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,247S

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,248G

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,249Y

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,278F

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)

1,308D

putative NTP binding site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,308D
CDD
cd01647 (RT_LTR)
putative active si...

1,244D

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,245L

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,246A

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,247S

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,248G

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,249Y

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,278F

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,279G

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,306Y

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,308D

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,309D

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,353L

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)

1,354G

putative active site
1,244D, 1,245L, 1,246A, 1,247S, 1,248G, 1,249Y, 1,278F, 1,279G, 1,306Y, 1,308D, 1,309D, 1,353L, 1,354G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,279G

putative nucleic acid binding site
1,279G
CDD
cd01647 (RT_LTR)
RNA/DNA hybrid bin...

1,455N

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,456A

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,457S

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,458T

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,492T

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,493A

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,494T

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,497E

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,522D

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,555H

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,569R

RNA/DNA hybrid binding site
1,455N, 1,456A, 1,457S, 1,458T, 1,492T, 1,493A, 1,494T, 1,497E, 1,522D, 1,555H, 1,569R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

None predicted.

Molecular Function

None predicted.

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC27599.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component