GBC25308.1

Protein

Length

490 amino acids

Protein family membership

GTP cyclohydrolase II, RibA (IPR000926)

Domains and repeats

Domain
103 - 151
GTP cyclohydrolase N-terminal (IPR022163)
152 - 266
GTP cyclohydrolase N-terminal (IPR022163)
272 - 445
GTP cyclohydrolase II (IPR032677)

1 50 100 150 200 250 300 350 400 450 490

Detailed signature matches

IPR000926

GTP cyclohydrolase II, RibA
1. cd00641 (GTP_cycloh...)
  
  233 - 477
  
  CDD
  cd00641 (GTP_cyclohydro2)
IPR022163

GTP cyclohydrolase N-terminal
1. PF12471 (GTP_CH_N)
  
  103 - 151
  
  Pfam
  PF12471 (GTP_CH_N)
  
  152 - 266
  
  Pfam
  PF12471 (GTP_CH_N)
IPR032677

GTP cyclohydrolase II
1. PF00925 (GTP_cycloh...)
  
  298 - 443
  
  Pfam
  PF00925 (GTP_cyclohydro2)
2. SSF142695 (RibA-like)
  
  272 - 445
  
  SUPERFAMILY
  SSF142695 (RibA-like)

Residue annotation

dimerization inter...

237A

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

238A

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

239V

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

240E

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

241P

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

242V

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

243W

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

261R

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

263L

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

264F

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

265E

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

289G

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

291S

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

293Y

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

315E

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

317N

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

318G

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

320D

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

321V

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

322F

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

323G

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

324S

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

326I

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

333L

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

334I

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

337M

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

354Y

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

356R

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

364E

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

365V

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

368Y

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

369L

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

371Y

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

372N

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)

375K

dimerization interface
237A, 238A, 239V, 240E, 241P, 242V, 243W, 261R, 263L, 264F, 265E, 289G, 291S, 293Y, 315E, 317N, 318G, 320D, 321V, 322F, 323G, 324S, 326I, 333L, 334I, 337M, 354Y, 356R, 364E, 365V, 368Y, 369L, 371Y, 372N, 375K
CDD
cd00641 (GTP_cyclohydro2)
active site cd00641

311R

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

312V

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

313H

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

314D

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

315E

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

316C

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

318G

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

327C

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

329C

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

332Y

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

357K

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

358E

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

359G

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

360R

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

367K

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

371Y

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

374R

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

382T

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

398D

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

400R

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

422S

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

423M

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

424S

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

427K

active site
311R, 312V, 313H, 314D, 315E, 316C, 318G, 327C, 329C, 332Y, 357K, 358E, 359G, 360R, 367K, 371Y, 374R, 382T, 398D, 400R, 422S, 423M, 424S, 427K
CDD
cd00641 (GTP_cyclohydro2)

GO term prediction

Biological Process

GO:0009231 riboflavin biosynthetic process

Molecular Function

GO:0003935 GTP cyclohydrolase II activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC25308.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component