GBC24699.1

Protein

Length

1,423 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
212 - 312
Retrotransposon gag domain (IPR005162)
424 - 458
Zinc finger, CCHC-type (IPR001878)
651 - 748
Aspartic peptidase domain (IPR021109)
956 - 1,135
Reverse transcriptase domain (IPR000477)

1 200 400 600 800 1000 1200 1423

Detailed signature matches

IPR005162

Retrotransposon gag domain
1. PF03732 (Retrotrans...)
  
  212 - 312
  
  Pfam
  PF03732 (Retrotrans_gag)
IPR001878

Zinc finger, CCHC-type
1. PS50158 (ZF_CCHC)
  
  440 - 453
  
  PROSITE profiles
  PS50158 (ZF_CCHC)
2. PF00098 (zf-CCHC)
  
  439 - 454
  
  Pfam
  PF00098 (zf-CCHC)
3. SM00343 (c2hcfinal6)
  
  439 - 455
  
  SMART
  SM00343 (c2hcfinal6)
4. SSF57756 (Retroviru...)
  
  424 - 458
  
  SUPERFAMILY
  SSF57756 (Retrovirus zinc finger-like domains)
IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  651 - 748
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  976 - 1,134
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  956 - 1,135
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR001969

Aspartic peptidase, active site
1. PS00141 (ASP_PROTEASE)
  
  661 - 672
  
  PROSITE patterns
  PS00141 (ASP_PROTEASE)

no IPR

Unintegrated signatures

Coil

375 - 395

COILS
Coil (Coil)
PF13975 (gag-asp_pr...)

651 - 741

Pfam
PF13975 (gag-asp_proteas)
SSF56672 (DNA/RNA p...)

901 - 1,334

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

652 - 740

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

959 - 1,135

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,229 - 1,348

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

503 - 551

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

664D

Catalytic residue
664D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

664D

catalytic motif
664D, 665S, 666G
CDD
cd00303 (retropepsin_like)

665S

catalytic motif
664D, 665S, 666G
CDD
cd00303 (retropepsin_like)

666G

catalytic motif
664D, 665S, 666G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

664D

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

666G

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

668A

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

692V

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

693V

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

694T

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)

733L

inhibitor binding site
664D, 666G, 668A, 692V, 693V, 694T, 733L
CDD
cd00303 (retropepsin_like)
Active site flap c...

692V

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

693V

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

694T

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

695A

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

699R

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

700N

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

701R

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)

702A

Active site flap
692V, 693V, 694T, 695A, 699R, 700N, 701R, 702A
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,022D

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,023L

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,024A

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,025S

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,026G

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,027F

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,056F

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)

1,086D

putative NTP binding site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,086D
CDD
cd01647 (RT_LTR)
putative active si...

1,022D

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,023L

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,024A

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,025S

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,026G

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,027F

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,056F

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,057G

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,084Y

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,086D

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,087D

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,131L

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)

1,132G

putative active site
1,022D, 1,023L, 1,024A, 1,025S, 1,026G, 1,027F, 1,056F, 1,057G, 1,084Y, 1,086D, 1,087D, 1,131L, 1,132G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,057G

putative nucleic acid binding site
1,057G
CDD
cd01647 (RT_LTR)
active site cd09274

1,233D

active site
1,233D, 1,275E, 1,300D, 1,343D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,275E

active site
1,233D, 1,275E, 1,300D, 1,343D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,300D

active site
1,233D, 1,275E, 1,300D, 1,343D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,343D

active site
1,233D, 1,275E, 1,300D, 1,343D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,233D

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,234A

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,235S

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,236G

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,270A

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,271V

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,272T

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,275E

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,300D

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,333H

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,347R

RNA/DNA hybrid binding site
1,233D, 1,234A, 1,235S, 1,236G, 1,270A, 1,271V, 1,272T, 1,275E, 1,300D, 1,333H, 1,347R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

GO:0006508 proteolysis

Molecular Function

GO:0003676 nucleic acid binding
GO:0004190 aspartic-type endopeptidase activity
GO:0008270 zinc ion binding

Cellular Component