GBC24018.1

Protein

Length

459 amino acids

Protein family membership

Fumarate lyase family (IPR000362)
- Argininosuccinate lyase (IPR009049)

Domains and repeats

Domain
9 - 458
L-Aspartase-like (IPR008948)
Domain
9 - 303
Fumarate lyase, N-terminal (IPR022761)
366 - 433
Argininosuccinate lyase, C-terminal (IPR029419)

1 50 100 150 200 250 300 350 400 459

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  150 - 168
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  105 - 123
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  234 - 261
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  278 - 294
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR009049

Argininosuccinate lyase
1. TIGR00838
  
  6 - 453
  
  TIGRFAMs
  TIGR00838 (TIGR00838)
2. MF_00006 (Arg_succ_...)
  
  5 - 455
  
  HAMAP
  MF_00006 (Arg_succ_lyase)
3. cd01359 (Argininosu...)
  
  25 - 457
  
  CDD
  cd01359 (Argininosuccinate_lyase)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  9 - 303
  
  Pfam
  PF00206 (Lyase_1)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  9 - 458
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR029419

Argininosuccinate lyase, C-terminal
1. PF14698 (ASL_C2)
  
  366 - 433
  
  Pfam
  PF14698 (ASL_C2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  278 - 287
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

PR00145 (ARGSUCLYASE)

196 - 212

PRINTS
PR00145 (ARGSUCLYASE)

278 - 294

PRINTS
PR00145 (ARGSUCLYASE)

145 - 165

PRINTS
PR00145 (ARGSUCLYASE)

104 - 126

PRINTS
PR00145 (ARGSUCLYASE)

234 - 258

PRINTS
PR00145 (ARGSUCLYASE)

313 - 332

PRINTS
PR00145 (ARGSUCLYASE)

Residue annotation

active sites cd01359

25S

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

29D

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

85D

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

87H

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

110S

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

111R

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

112N

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

115V

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

157T

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

158H

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

234R

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

277T

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

279S

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

287N

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

289D

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

292E

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

319Y

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

321K

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

324Q

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

326D

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)

327K

active sites
25S, 29D, 85D, 87H, 110S, 111R, 112N, 115V, 157T, 158H, 234R, 277T, 279S, 287N, 289D, 292E, 319Y, 321K, 324Q, 326D, 327K
CDD
cd01359 (Argininosuccinate_lyase)
tetramer interface...

100S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

103G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

106H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

107T

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

156Y

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

157T

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

158H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

159L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

160Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

161R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

162A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

163Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

169H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

173A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

174Y

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

180E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

183E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

184R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

187Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

191R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

202L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

203A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

204G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

205N

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

206P

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

208N

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

211R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

225H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

226N

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

227S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

228L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

229L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

232S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

233D

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

235D

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

239E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

242F

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

246L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

249I

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

250H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

252S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

253R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

256E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

257D

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

262S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

263T

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

266F

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

274A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

280S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

281L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

282M

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

283P

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

285K

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

286K

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

287N

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

289D

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

292E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

293L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

295R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

296G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

297K

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

298S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

299G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

300R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

302F

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

303G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

304Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

307G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

309L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

310M

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

311T

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

319Y

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

320N

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

321K

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

322D

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

325E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

328E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

339G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

342Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

368A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

373E

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

377R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

382F

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

383R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

386H

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

389A

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

435R

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

437S

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

438L

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

439G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

440G

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

441T

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

449Q

tetramer interface
100S, 103G, 106H, 107T, 156Y, 157T, 158H, 159L, 160Q, 161R, 162A, 163Q, 169H, 173A, 174Y, 180E, 183E, 184R, 187Q, 191R, 202L, 203A, 204G, 205N, 206P, 208N, 211R, 225H, 226N, 227S, 228L, 229L, 232S, 233D, 235D, 239E, 242F, 246L, 249I, 250H, 252S, 253R, 256E, 257D, 262S, 263T, 266F, 274A, 280S, 281L, 282M, 283P, 285K, 286K, 287N, 289D, 292E, 293L, 295R, 296G, 297K, 298S, 299G, 300R, 302F, 303G, 304Q, 307G, 309L, 310M, 311T, 319Y, 320N, 321K, 322D, 325E, 328E, 339G, 342Q, 368A, 373E, 377R, 382F, 383R, 386H, 389A, 435R, 437S, 438L, 439G, 440G, 441T, 449Q
CDD
cd01359 (Argininosuccinate_lyase)

GO term prediction

Biological Process

GO:0042450 arginine biosynthetic process via ornithine

Molecular Function

GO:0003824 catalytic activity
GO:0004056 argininosuccinate lyase activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features