GBC20173.1

Protein

Length

223 amino acids

Protein family membership

GTP cyclohydrolase I (IPR001474)

Domains and repeats

Domain
43 - 219
GTP cyclohydrolase I domain (IPR020602)

1 50 100 150 223

Detailed signature matches

IPR001474

GTP cyclohydrolase I
1. TIGR00063
  
  43 - 220
  
  TIGRFAMs
  TIGR00063 (TIGR00063)
2. MF_00223 (FolE)
  
  38 - 220
  
  HAMAP
  MF_00223 (FolE)
IPR020602

GTP cyclohydrolase I domain
1. PF01227 (GTP_cycloh...)
  
  43 - 219
  
  Pfam
  PF01227 (GTP_cyclohydroI)
IPR018234

GTP cyclohydrolase I, conserved site
1. PS00860 (GTP_CYCLOH...)
  
  147 - 157
  
  PROSITE patterns
  PS00860 (GTP_CYCLOHYDROL_1_2)
2. PS00859 (GTP_CYCLOH...)
  
  99 - 115
  
  PROSITE patterns
  PS00859 (GTP_CYCLOHYDROL_1_1)

no IPR

Unintegrated signatures

SSF55620 (Tetrahydr...)

12 - 221

SUPERFAMILY
SSF55620 (Tetrahydrobiopterin biosynthesis enzymes-like)
cd00642 (GTP_cycloh...)

37 - 220

CDD
cd00642 (GTP_cyclohydro1)

Residue annotation

homodecamer interf...

37E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

38R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

41K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

42L

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

45A

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

49I

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

52C

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

53I

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

55E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

57P

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

59R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

61G

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

62L

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

63Q

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

65T

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

66P

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

68R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

72A

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

75F

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

80Y

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

91A

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

93F

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

97H

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

98D

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

99E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

100M

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

102I

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

103V

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

104K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

105D

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

107E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

109F

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

113E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

114H

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

117V

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

118P

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

120T

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

122K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

129P

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

130N

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

132S

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

136L

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

137S

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

138K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

141R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

151Q

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

152V

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

153Q

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

155R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

158K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

168L

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

181H

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

182L

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

183C

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

186M

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

187R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

192P

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

193G

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

195S

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

196T

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

197V

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

199S

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

200V

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

201M

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

206R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

207E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

210K

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

212R

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

213E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)

214E

homodecamer interface
37E, 38R, 41K, 42L, 45A, 49I, 52C, 53I, 55E, 57P, 59R, 61G, 62L, 63Q, 65T, 66P, 68R, 72A, 75F, 80Y, 91A, 93F, 97H, 98D, 99E, 100M, 102I, 103V, 104K, 105D, 107E, 109F, 113E, 114H, 117V, 118P, 120T, 122K, 129P, 130N, 132S, 136L, 137S, 138K, 141R, 151Q, 152V, 153Q, 155R, 158K, 168L, 181H, 182L, 183C, 186M, 187R, 192P, 193G, 195S, 196T, 197V, 199S, 200V, 201M, 206R, 207E, 210K, 212R, 213E, 214E
CDD
cd00642 (GTP_cyclohydro1)
active site cd00642

68R

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

71Q

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

112C

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

114H

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

115H

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

134I

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

136L

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

137S

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

141R

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

152V

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

153Q

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

154E

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

181H

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

183C

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)

187R

active site
68R, 71Q, 112C, 114H, 115H, 134I, 136L, 137S, 141R, 152V, 153Q, 154E, 181H, 183C, 187R
CDD
cd00642 (GTP_cyclohydro1)
zinc binding site ...

112C

zinc binding site
112C, 114H, 115H, 183C
CDD
cd00642 (GTP_cyclohydro1)

114H

zinc binding site
112C, 114H, 115H, 183C
CDD
cd00642 (GTP_cyclohydro1)

115H

zinc binding site
112C, 114H, 115H, 183C
CDD
cd00642 (GTP_cyclohydro1)

183C

zinc binding site
112C, 114H, 115H, 183C
CDD
cd00642 (GTP_cyclohydro1)
putative catalytic...

112C

putative catalytic site residues
112C, 114H, 115H, 181H, 183C
CDD
cd00642 (GTP_cyclohydro1)

114H

putative catalytic site residues
112C, 114H, 115H, 181H, 183C
CDD
cd00642 (GTP_cyclohydro1)

115H

putative catalytic site residues
112C, 114H, 115H, 181H, 183C
CDD
cd00642 (GTP_cyclohydro1)

181H

putative catalytic site residues
112C, 114H, 115H, 181H, 183C
CDD
cd00642 (GTP_cyclohydro1)

183C

putative catalytic site residues
112C, 114H, 115H, 181H, 183C
CDD
cd00642 (GTP_cyclohydro1)
GTP-CH-I/GFRP inte...

162V

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

165Q

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

171Q

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

173V

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

202L

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

203G

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

204V

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

206R

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

207E

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

208Q

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

209A

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

210K

GTP-CH-I/GFRP interaction surface
162V, 165Q, 171Q, 173V, 202L, 203G, 204V, 206R, 207E, 208Q, 209A, 210K
CDD
cd00642 (GTP_cyclohydro1)

GO term prediction

Biological Process

GO:0046654 tetrahydrofolate biosynthetic process

Molecular Function

GO:0003934 GTP cyclohydrolase I activity

Cellular Component

GO:0005737 cytoplasm

Filter view on

Entry type

Status

Per-residue features

GBC20173.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component