GBC19201.1

Protein

Length

164 amino acids

Protein family membership

Glyoxalase I (IPR004361)

Domains and repeats

Domain
1 - 155
Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase (IPR029068)
Glyoxalase/fosfomycin resistance/dioxygenase domain (IPR004360)

1 20 40 60 80 100 120 140 164

Detailed signature matches

IPR004361

Glyoxalase I
1. TIGR00068
  
  6 - 158
  
  TIGRFAMs
  TIGR00068 (TIGR00068)
IPR029068

Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase
1. SSF54593 (Glyoxalas...)
  
  1 - 155
  
  SUPERFAMILY
  SSF54593 (Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase)
IPR004360

Glyoxalase/fosfomycin resistance/dioxygenase domain
1. PF00903 (Glyoxalase)
  
  10 - 152
  
  Pfam
  PF00903 (Glyoxalase)
IPR018146

Glyoxalase I, conserved site
1. PS00934 (GLYOXALASE...)
  
  12 - 33
  
  PROSITE patterns
  PS00934 (GLYOXALASE_I_1)

no IPR

Unintegrated signatures

cd07233 (Glyoxalase_I)

10 - 153

CDD
cd07233 (Glyoxalase_I)

Residue annotation

dimer interface cd...

10F

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

11N

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

12H

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

13T

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

14M

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

16R

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

20P

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

21Q

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

24L

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

25K

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

28E

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

29E

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

32G

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

35L

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

38K

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

39A

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

49Y

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

53Y

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

75A

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

77L

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

78E

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

82N

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

83W

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

102G

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

103F

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

104G

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

105H

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

106L

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

107A

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

108I

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

109T

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

110V

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

111D

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

119R

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

148Y

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)

151E

dimer interface
10F, 11N, 12H, 13T, 14M, 16R, 20P, 21Q, 24L, 25K, 28E, 29E, 32G, 35L, 38K, 39A, 49Y, 53Y, 75A, 77L, 78E, 82N, 83W, 102G, 103F, 104G, 105H, 106L, 107A, 108I, 109T, 110V, 111D, 119R, 148Y, 151E
CDD
cd07233 (Glyoxalase_I)
active site cd07233

12H

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

16R

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

41F

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

46F

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

48L

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

78E

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

80T

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

82N

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

105H

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

129K

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

139I

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

141F

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

149W

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)

151E

active site
12H, 16R, 41F, 46F, 48L, 78E, 80T, 82N, 105H, 129K, 139I, 141F, 149W, 151E
CDD
cd07233 (Glyoxalase_I)
metal binding site...

12H

metal binding site
12H, 78E, 105H, 151E
CDD
cd07233 (Glyoxalase_I)

78E

metal binding site
12H, 78E, 105H, 151E
CDD
cd07233 (Glyoxalase_I)

105H

metal binding site
12H, 78E, 105H, 151E
CDD
cd07233 (Glyoxalase_I)

151E

metal binding site
12H, 78E, 105H, 151E
CDD
cd07233 (Glyoxalase_I)
glutathione bindin...

16R

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

41F

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

46F

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

48L

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

80T

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

82N

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

129K

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

139I

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

141F

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

149W

glutathione binding site
16R, 41F, 46F, 48L, 80T, 82N, 129K, 139I, 141F, 149W
CDD
cd07233 (Glyoxalase_I)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0004462 lactoylglutathione lyase activity
GO:0046872 metal ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC19201.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component