GBC18663.1

Protein

Length

1,139 amino acids

Protein family membership

PAB-dependent poly(A)-specific ribonuclease subunit PAN2 (IPR030843)

Domains and repeats

Domain
20 - 303
WD40-repeat-containing domain (IPR017986)
474 - 832
Ubiquitin specific protease domain (IPR028889)
PAN2 domain (IPR028881)
882 - 1,066
Ribonuclease H-like domain (IPR012337)
Exonuclease, RNase T/DNA polymerase III (IPR013520)

1 200 400 600 800 1000 1139

Detailed signature matches

IPR030843

PAB-dependent poly(A)-specific ribonuclease subunit PAN2
1. MF_03182 (PAN2)
  
  1 - 1,090
  
  HAMAP
  MF_03182 (PAN2)
IPR017986

WD40-repeat-containing domain
1. SSF50978 (WD40 repe...)
  
  20 - 303
  
  SUPERFAMILY
  SSF50978 (WD40 repeat-like)
IPR028889

Ubiquitin specific protease domain
1. PS50235 (USP_3)
  
  474 - 832
  
  PROSITE profiles
  PS50235 (USP_3)
IPR028881

PAN2 domain
1. PF13423 (UCH_1)
  
  474 - 806
  
  Pfam
  PF13423 (UCH_1)
IPR012337

Ribonuclease H-like domain
1. SSF53098 (Ribonucle...)
  
  883 - 1,064
  
  SUPERFAMILY
  SSF53098 (Ribonuclease H-like)
IPR013520

Exonuclease, RNase T/DNA polymerase III
1. SM00479 (exoiiiendus)
  
  882 - 1,066
  
  SMART
  SM00479 (exoiiiendus)
2. PF00929 (RNase_T)
  
  884 - 1,057
  
  Pfam
  PF00929 (RNase_T)

no IPR

Unintegrated signatures

SSF54001 (Cysteine ...)

472 - 850

SUPERFAMILY
SSF54001 (Cysteine proteinases)
cd06143 (PAN2_exo)

884 - 1,058

CDD
cd06143 (PAN2_exo)
mobidb-lite (disord...)

397 - 435

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

substrate binding ...

887D

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

888A

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

889E

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

890F

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

892A

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

948L

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

952S

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

991H

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

992G

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

994K

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

995K

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,044H

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,049D

substrate binding site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)
active site cd06143

887D

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

888A

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

889E

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

890F

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

892A

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

948L

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

952S

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

991H

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

992G

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

994K

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

995K

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

996D

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,044H

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,049D

active site
887D, 888A, 889E, 890F, 892A, 948L, 952S, 991H, 992G, 994K, 995K, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)
catalytic site cd0...

887D

catalytic site
887D, 889E, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

889E

catalytic site
887D, 889E, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

996D

catalytic site
887D, 889E, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,044H

catalytic site
887D, 889E, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

1,049D

catalytic site
887D, 889E, 996D, 1,044H, 1,049D
CDD
cd06143 (PAN2_exo)

GO term prediction

Biological Process

GO:0000289 nuclear-transcribed mRNA poly(A) tail shortening
GO:0006397 mRNA processing

Molecular Function

GO:0003676 nucleic acid binding
GO:0004535 poly(A)-specific ribonuclease activity
GO:0005515 protein binding

Cellular Component

GO:0031251 PAN complex

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Entry type

Status

Per-residue features