GBC17847.1

Protein

Length

2,257 amino acids

Protein family membership

None predicted.

Domains and repeats

Domain
852 - 954
Retrotransposon gag domain (IPR005162)
1,084 - 1,100
Zinc finger, CCHC-type (IPR001878)
1,222 - 1,252
Zinc finger, CCHC-type (IPR001878)
1,296 - 1,389
Aspartic peptidase domain (IPR021109)
1,581 - 1,760
Reverse transcriptase domain (IPR000477)
2,050 - 2,253
P-loop containing nucleoside triphosphate hydrolase (IPR027417)

1 500 1000 1500 2000 2257

Detailed signature matches

IPR005162

Retrotransposon gag domain
1. PF03732 (Retrotrans...)
  
  852 - 954
  
  Pfam
  PF03732 (Retrotrans_gag)
IPR001878

Zinc finger, CCHC-type
1. PS50158 (ZF_CCHC)
  
  1,235 - 1,251
  
  PROSITE profiles
  PS50158 (ZF_CCHC)
  
  1,085 - 1,100
  
  PROSITE profiles
  PS50158 (ZF_CCHC)
2. PF00098 (zf-CCHC)
  
  1,235 - 1,251
  
  Pfam
  PF00098 (zf-CCHC)
3. SM00343 (c2hcfinal6)
  
  1,084 - 1,100
  
  SMART
  SM00343 (c2hcfinal6)
  
  1,235 - 1,251
  
  SMART
  SM00343 (c2hcfinal6)
4. SSF57756 (Retroviru...)
  
  1,222 - 1,252
  
  SUPERFAMILY
  SSF57756 (Retrovirus zinc finger-like domains)
IPR021109

Aspartic peptidase domain
1. SSF50630 (Acid prot...)
  
  1,296 - 1,389
  
  SUPERFAMILY
  SSF50630 (Acid proteases)
IPR000477

Reverse transcriptase domain
1. PF00078 (RVT_1)
  
  1,602 - 1,759
  
  Pfam
  PF00078 (RVT_1)
2. PS50878 (RT_POL)
  
  1,581 - 1,760
  
  PROSITE profiles
  PS50878 (RT_POL)
IPR027417

P-loop containing nucleoside triphosphate hydrolase
1. SSF52540 (P-loop co...)
  
  2,050 - 2,253
  
  SUPERFAMILY
  SSF52540 (P-loop containing nucleoside triphosphate hydrolases)

no IPR

Unintegrated signatures

Coil

969 - 989

COILS
Coil (Coil)

582 - 602

COILS
Coil (Coil)

634 - 658

COILS
Coil (Coil)

473 - 508

COILS
Coil (Coil)
PF13650 (Asp_protea...)

1,304 - 1,383

Pfam
PF13650 (Asp_protease_2)
SSF56672 (DNA/RNA p...)

1,524 - 1,959

SUPERFAMILY
SSF56672 (DNA/RNA polymerases)
cd00303 (retropepsi...)

1,301 - 1,384

CDD
cd00303 (retropepsin_like)
cd01647 (RT_LTR)

1,584 - 1,760

CDD
cd01647 (RT_LTR)
cd09274 (RNase_HI_R...)

1,854 - 1,973

CDD
cd09274 (RNase_HI_RT_Ty3)
mobidb-lite (disord...)

720 - 739

MobiDB Lite
mobidb-lite (disorder_prediction)

1,174 - 1,219

MobiDB Lite
mobidb-lite (disorder_prediction)

659 - 713

MobiDB Lite
mobidb-lite (disorder_prediction)

1,427 - 1,459

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

Catalytic residue ...

1,314D

Catalytic residue
1,314D
CDD
cd00303 (retropepsin_like)
catalytic motif cd...

1,314D

catalytic motif
1,314D, 1,315T, 1,316G
CDD
cd00303 (retropepsin_like)

1,315T

catalytic motif
1,314D, 1,315T, 1,316G
CDD
cd00303 (retropepsin_like)

1,316G

catalytic motif
1,314D, 1,315T, 1,316G
CDD
cd00303 (retropepsin_like)
inhibitor binding ...

1,314D

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,316G

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,318G

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,342L

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,343T

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,344I

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)

1,383I

inhibitor binding site
1,314D, 1,316G, 1,318G, 1,342L, 1,343T, 1,344I, 1,383I
CDD
cd00303 (retropepsin_like)
Active site flap c...

1,342L

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,343T

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,344I

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,345A

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,349N

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,350I

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,351A

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)

1,352S

Active site flap
1,342L, 1,343T, 1,344I, 1,345A, 1,349N, 1,350I, 1,351A, 1,352S
CDD
cd00303 (retropepsin_like)
putative NTP bindi...

1,647D

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,648L

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,649A

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,650A

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,651G

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,652Y

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,681F

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)

1,711D

putative NTP binding site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,711D
CDD
cd01647 (RT_LTR)
putative active si...

1,647D

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,648L

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,649A

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,650A

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,651G

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,652Y

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,681F

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,682G

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,709Y

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,711D

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,712D

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,756L

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)

1,757G

putative active site
1,647D, 1,648L, 1,649A, 1,650A, 1,651G, 1,652Y, 1,681F, 1,682G, 1,709Y, 1,711D, 1,712D, 1,756L, 1,757G
CDD
cd01647 (RT_LTR)
putative nucleic a...

1,682G

putative nucleic acid binding site
1,682G
CDD
cd01647 (RT_LTR)
active site cd09274

1,858D

active site
1,858D, 1,900E, 1,925D, 1,968D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,900E

active site
1,858D, 1,900E, 1,925D, 1,968D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,925D

active site
1,858D, 1,900E, 1,925D, 1,968D
CDD
cd09274 (RNase_HI_RT_Ty3)

1,968D

active site
1,858D, 1,900E, 1,925D, 1,968D
CDD
cd09274 (RNase_HI_RT_Ty3)
RNA/DNA hybrid bin...

1,858D

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,859G

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,860S

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,861K

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,895P

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,896P

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,897T

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,900E

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,925D

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,958H

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

1,972R

RNA/DNA hybrid binding site
1,858D, 1,859G, 1,860S, 1,861K, 1,895P, 1,896P, 1,897T, 1,900E, 1,925D, 1,958H, 1,972R
CDD
cd09274 (RNase_HI_RT_Ty3)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0003676 nucleic acid binding
GO:0008270 zinc ion binding

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC17847.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component