GBC16027.1

Protein

Length

969 amino acids

Protein family membership

Short-chain dehydrogenase/reductase SDR (IPR002347)

Domains and repeats

Domain
2 - 164
NAD(P)-binding domain (IPR016040)
225 - 470
NAD(P)-binding domain (IPR016040)
547 - 691
HotDog domain (IPR029069)
700 - 815
HotDog domain (IPR029069)
MaoC-like domain (IPR002539)
845 - 960
SCP2 sterol-binding domain (IPR003033)

1 100 200 300 400 500 600 700 800 900 969

Detailed signature matches

IPR002347

Short-chain dehydrogenase/reductase SDR
1. PF00106 (adh_short)
  
  230 - 416
  
  Pfam
  PF00106 (adh_short)
  
  2 - 110
  
  Pfam
  PF00106 (adh_short)
2. PR00080 (SDRFAMILY)
  
  58 - 66
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  5 - 16
  
  PRINTS
  PR00080 (SDRFAMILY)
  
  78 - 97
  
  PRINTS
  PR00080 (SDRFAMILY)
3. PR00081 (GDHRDH)
  
  384 - 403
  
  PRINTS
  PR00081 (GDHRDH)
  
  311 - 322
  
  PRINTS
  PR00081 (GDHRDH)
  
  358 - 374
  
  PRINTS
  PR00081 (GDHRDH)
  
  231 - 248
  
  PRINTS
  PR00081 (GDHRDH)
  
  405 - 422
  
  PRINTS
  PR00081 (GDHRDH)
IPR016040

NAD(P)-binding domain
1. SSF51735 (NAD(P)-bi...)
  
  2 - 164
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
  
  225 - 470
  
  SUPERFAMILY
  SSF51735 (NAD(P)-binding Rossmann-fold domains)
IPR029069

HotDog domain
1. SSF54637 (Thioester...)
  
  700 - 815
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
  
  547 - 691
  
  SUPERFAMILY
  SSF54637 (Thioesterase/thiol ester dehydrase-isomerase)
IPR002539

MaoC-like domain
1. PF01575 (MaoC_dehyd...)
  
  700 - 813
  
  Pfam
  PF01575 (MaoC_dehydratas)
IPR003033

SCP2 sterol-binding domain
1. SSF55718 (SCP-like)
  
  845 - 960
  
  SUPERFAMILY
  SSF55718 (SCP-like)
2. PF02036 (SCP2)
  
  855 - 960
  
  Pfam
  PF02036 (SCP2)
IPR020904

Short-chain dehydrogenase/reductase, conserved site
1. PS00061 (ADH_SHORT)
  
  65 - 93
  
  PROSITE patterns
  PS00061 (ADH_SHORT)
  
  371 - 399
  
  PROSITE patterns
  PS00061 (ADH_SHORT)

no IPR

Unintegrated signatures

SM00822 (PKS_KR)

230 - 423

SMART
SM00822 (PKS_KR)
cd03448 (HDE_HSD)

702 - 823

CDD
cd03448 (HDE_HSD)
cd05353 (hydroxyacy...)

225 - 474

CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
mobidb-lite (disord...)

688 - 709

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

homodimer interfac...

225L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

252L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

327S

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

328F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

329A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

331M

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

332T

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

333D

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

336W

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

337D

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

340Q

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

344L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

345R

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

348Y

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

351T

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

352K

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

355W

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

356P

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

372S

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

373V

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

374G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

375L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

376Y

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

377G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

378N

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

379F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

380G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

382A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

385S

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

386T

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

389L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

390G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

392L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

393G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

394F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

396N

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

397T

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

398L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

400L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

401E

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

403R

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

404K

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

406N

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

429M

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

432A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

433F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

437Y

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

440P

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

441F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

443G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

444Y

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

445L

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

452S

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

456V

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

457F

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

458E

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

460G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

461G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

462G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

463W

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

464A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

465A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

466Q

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

467V

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

468R

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

469W

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

470Q

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

471R

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

472A

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

473G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

474G

homodimer interface
225L, 252L, 327S, 328F, 329A, 331M, 332T, 333D, 336W, 337D, 340Q, 344L, 345R, 348Y, 351T, 352K, 355W, 356P, 372S, 373V, 374G, 375L, 376Y, 377G, 378N, 379F, 380G, 382A, 385S, 386T, 389L, 390G, 392L, 393G, 394F, 396N, 397T, 398L, 400L, 401E, 403R, 404K, 406N, 429M, 432A, 433F, 437Y, 440P, 441F, 443G, 444Y, 445L, 452S, 456V, 457F, 458E, 460G, 461G, 462G, 463W, 464A, 465A, 466Q, 467V, 468R, 469W, 470Q, 471R, 472A, 473G, 474G
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
NAD binding site c...

236G

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

239G

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

240G

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

241L

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

259N

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

260D

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

261L

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

263V

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

295S

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

296V

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

319N

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

320A

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

321G

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

322I

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

342V

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

343H

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

369T

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

370A

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

371S

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

384Y

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

388K

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

414P

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

415N

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

416A

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

418T

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

419R

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

420M

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

421T

NAD binding site
236G, 239G, 240G, 241L, 259N, 260D, 261L, 263V, 295S, 296V, 319N, 320A, 321G, 322I, 342V, 343H, 369T, 370A, 371S, 384Y, 388K, 414P, 415N, 416A, 418T, 419R, 420M, 421T
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
active site cd05353

343H

active site
343H, 371S, 384Y, 388K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

371S

active site
343H, 371S, 384Y, 388K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

384Y

active site
343H, 371S, 384Y, 388K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)

388K

active site
343H, 371S, 384Y, 388K
CDD
cd05353 (hydroxyacyl-CoA-like_DH_SDR_c-like)
dimer interaction ...

717N

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

720A

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

723R

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

724L

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

728Y

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

730P

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)

734D

dimer interaction site
717N, 720A, 723R, 724L, 728Y, 730P, 734D
CDD
cd03448 (HDE_HSD)
substrate-binding ...

721L

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

727D

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

729N

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

732H

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

749H

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

751M

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

754Y

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

757S

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

761I

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

773F

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

776I

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

778A

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

780L

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

794M

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

803F

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

805T

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

814C

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)

820V

substrate-binding tunnel
721L, 727D, 729N, 732H, 749H, 751M, 754Y, 757S, 761I, 773F, 776I, 778A, 780L, 794M, 803F, 805T, 814C, 820V
CDD
cd03448 (HDE_HSD)
active site cd03448

722Y

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

726G

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

727D

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

729N

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

732H

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

747I

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

750G

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)

751M

active site
722Y, 726G, 727D, 729N, 732H, 747I, 750G, 751M
CDD
cd03448 (HDE_HSD)
catalytic site cd0...

727D

catalytic site
727D, 729N, 732H, 750G
CDD
cd03448 (HDE_HSD)

729N

catalytic site
727D, 729N, 732H, 750G
CDD
cd03448 (HDE_HSD)

732H

catalytic site
727D, 729N, 732H, 750G
CDD
cd03448 (HDE_HSD)

750G

catalytic site
727D, 729N, 732H, 750G
CDD
cd03448 (HDE_HSD)
substrate binding ...

758G

substrate binding site
758G, 761I, 771N, 773F
CDD
cd03448 (HDE_HSD)

761I

substrate binding site
758G, 761I, 771N, 773F
CDD
cd03448 (HDE_HSD)

771N

substrate binding site
758G, 761I, 771N, 773F
CDD
cd03448 (HDE_HSD)

773F

substrate binding site
758G, 761I, 771N, 773F
CDD
cd03448 (HDE_HSD)

GO term prediction

Biological Process

None predicted.

Molecular Function

GO:0016491 oxidoreductase activity

Cellular Component

None predicted.

Filter view on

Entry type

Status

Per-residue features

GBC16027.1

Protein family membership

Domains and repeats

Detailed signature matches

Residue annotation

GO term prediction

Biological Process

Molecular Function

Cellular Component