GBC15937.1

Protein

Length

241 amino acids

Protein family membership

Proliferating cell nuclear antigen, PCNA (IPR000730)

Domains and repeats

Domain
1 - 125
Proliferating cell nuclear antigen, PCNA, N-terminal (IPR022648)
129 - 237
Proliferating cell nuclear antigen, PCNA, C-terminal (IPR022649)

1 50 100 150 200 241

Detailed signature matches

IPR000730

Proliferating cell nuclear antigen, PCNA
1. TIGR00590
  
  1 - 236
  
  TIGRFAMs
  TIGR00590 (TIGR00590)
2. PR00339 (PCNACYCLIN)
  
  56 - 80
  
  PRINTS
  PR00339 (PCNACYCLIN)
  
  111 - 133
  
  PRINTS
  PR00339 (PCNACYCLIN)
  
  10 - 29
  
  PRINTS
  PR00339 (PCNACYCLIN)
  
  34 - 52
  
  PRINTS
  PR00339 (PCNACYCLIN)
  
  204 - 218
  
  PRINTS
  PR00339 (PCNACYCLIN)
IPR022648

Proliferating cell nuclear antigen, PCNA, N-terminal
1. PF00705 (PCNA_N)
  
  1 - 125
  
  Pfam
  PF00705 (PCNA_N)
IPR022649

Proliferating cell nuclear antigen, PCNA, C-terminal
1. PF02747 (PCNA_C)
  
  129 - 237
  
  Pfam
  PF02747 (PCNA_C)
IPR022659

Proliferating cell nuclear antigen, PCNA, conserved site
1. PS00293 (PCNA_2)
  
  61 - 79
  
  PROSITE patterns
  PS00293 (PCNA_2)
2. PS01251 (PCNA_1)
  
  34 - 57
  
  PROSITE patterns
  PS01251 (PCNA_1)

no IPR

Unintegrated signatures

SSF55979 (DNA clamp)

129 - 237

SUPERFAMILY
SSF55979 (DNA clamp)

1 - 127

SUPERFAMILY
SSF55979 (DNA clamp)
cd00577 (PCNA)

4 - 237

CDD
cd00577 (PCNA)

Residue annotation

putative DNA bindi...

13K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

14K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

20K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

77K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

80K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

147R

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

150R

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

211K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)

218K

putative DNA binding site
13K, 14K, 20K, 77K, 80K, 147R, 150R, 211K, 218K
CDD
cd00577 (PCNA)
PCNA/WAF1-CIP1 pro...

27N

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

29D

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

40M

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

67S

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

69G

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

120M

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

121D

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

122I

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)

123D

PCNA/WAF1-CIP1 protein binding site
27N, 29D, 40M, 67S, 69G, 120M, 121D, 122I, 123D
CDD
cd00577 (PCNA)
PCNA/FEN-1 protein...

40M

PCNA/FEN-1 protein interaction site
40M, 47L
CDD
cd00577 (PCNA)

47L

PCNA/FEN-1 protein interaction site
40M, 47L
CDD
cd00577 (PCNA)
trimer interface c...

77K

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

80K

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

81C

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

82A

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

112V

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

113S

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

114E

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

115Y

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

116E

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

117L

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

118K

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

144E

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

147R

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

148I

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

150R

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

151D

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

174G

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

177G

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

178T

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

180S

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

181V

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

182K

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

183L

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)

184K

trimer interface
77K, 80K, 81C, 82A, 112V, 113S, 114E, 115Y, 116E, 117L, 118K, 144E, 147R, 148I, 150R, 151D, 174G, 177G, 178T, 180S, 181V, 182K, 183L, 184K
CDD
cd00577 (PCNA)
PCNA/RFCL protein ...

209S

PCNA/RFCL protein interaction site
209S
CDD
cd00577 (PCNA)

GO term prediction

Biological Process

GO:0006275 regulation of DNA replication

Molecular Function

GO:0003677 DNA binding
GO:0030337 DNA polymerase processivity factor activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features