GBC14120.1

Protein

Length

640 amino acids

Protein family membership

Ku70 (IPR006165)

Domains and repeats

Domain
39 - 259
von Willebrand factor, type A (IPR002035)
279 - 470
Ku70/Ku80 beta-barrel domain (IPR006164)
492 - 564
Ku70/Ku80 C-terminal arm (IPR005160)
Domain
42 - 263
Ku70/Ku80, N-terminal alpha/beta (IPR005161)
Domain
262 - 547
SPOC-like, C-terminal domain (IPR016194)

1 100 200 300 400 500 640

Detailed signature matches

IPR006165

Ku70
1. PIRSF003033 (Ku70)
  
  10 - 636
  
  PIRSF
  PIRSF003033 (Ku70)
2. TIGR00578
  
  36 - 634
  
  TIGRFAMs
  TIGR00578 (TIGR00578)
IPR002035

von Willebrand factor, type A
1. SSF53300 (vWA-like)
  
  39 - 259
  
  SUPERFAMILY
  SSF53300 (vWA-like)
IPR005161

Ku70/Ku80, N-terminal alpha/beta
1. PF03731 (Ku_N)
  
  42 - 263
  
  Pfam
  PF03731 (Ku_N)
IPR016194

SPOC-like, C-terminal domain
1. SSF100939 (SPOC dom...)
  
  262 - 547
  
  SUPERFAMILY
  SSF100939 (SPOC domain-like)
IPR006164

Ku70/Ku80 beta-barrel domain
1. PF02735 (Ku)
  
  279 - 465
  
  Pfam
  PF02735 (Ku)
2. SM00559 (ku_4)
  
  324 - 470
  
  SMART
  SM00559 (ku_4)
IPR005160

Ku70/Ku80 C-terminal arm
1. PF03730 (Ku_C)
  
  492 - 564
  
  Pfam
  PF03730 (Ku_C)

no IPR

Unintegrated signatures

cd00788 (KU70)

262 - 547

CDD
cd00788 (KU70)
cd01458 (vWA_ku)

40 - 257

CDD
cd01458 (vWA_ku)
mobidb-lite (disord...)

565 - 588

MobiDB Lite
mobidb-lite (disorder_prediction)

1 - 25

MobiDB Lite
mobidb-lite (disorder_prediction)

Residue annotation

interface residues...

82L

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

85D

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

87T

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

119P

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

121I

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

252S

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

253Q

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

255M

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

256A

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)

257K

interface residues
82L, 85D, 87T, 119P, 121I, 252S, 253Q, 255M, 256A, 257K
CDD
cd01458 (vWA_ku)
DNA binding site c...

262R

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

263S

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

264L

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

265F

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

266S

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

289A

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

292I

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

296K

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

299P

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

316T

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

354R

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)

419R

DNA binding site
262R, 263S, 264L, 265F, 266S, 289A, 292I, 296K, 299P, 316T, 354R, 419R
CDD
cd00788 (KU70)
heterodimer interf...

281L

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

289A

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

292I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

293E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

294K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

299P

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

300R

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

301M

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

302I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

306S

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

307E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

312A

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

313E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

314S

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

315R

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

317K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

318Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

319V

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

331D

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

332I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

333K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

335C

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

336Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

337E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

338Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

341E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

342K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

344A

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

345F

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

349E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

353L

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

357G

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

364I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

366F

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

367K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

373K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

377N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

385Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

395R

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

396R

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

404K

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

408M

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

413I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

415Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

434E

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

449N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

454P

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

455F

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

456A

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

457D

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

458D

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

459I

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

460R

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

470P

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

471A

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

475M

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

479L

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

486L

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

487H

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

492F

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

497F

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

498N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

499N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

503G

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

508V

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

510Q

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

512L

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

524D

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

527N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

528P

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

530Y

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

545N

heterodimer interface
281L, 289A, 292I, 293E, 294K, 299P, 300R, 301M, 302I, 306S, 307E, 312A, 313E, 314S, 315R, 317K, 318Y, 319V, 331D, 332I, 333K, 335C, 336Y, 337E, 338Y, 341E, 342K, 344A, 345F, 349E, 353L, 357G, 364I, 366F, 367K, 373K, 377N, 385Y, 395R, 396R, 404K, 408M, 413I, 415Y, 434E, 449N, 454P, 455F, 456A, 457D, 458D, 459I, 460R, 470P, 471A, 475M, 479L, 486L, 487H, 492F, 497F, 498N, 499N, 503G, 508V, 510Q, 512L, 524D, 527N, 528P, 530Y, 545N
CDD
cd00788 (KU70)

GO term prediction

Biological Process

GO:0000723 telomere maintenance
GO:0006303 double-strand break repair via nonhomologous end joining

Molecular Function

GO:0003677 DNA binding
GO:0003684 damaged DNA binding
GO:0004003 ATP-dependent DNA helicase activity
GO:0042162 telomeric DNA binding

Cellular Component

GO:0005634 nucleus
GO:0043564 Ku70:Ku80 complex

Filter view on

Entry type

Status

Per-residue features