GBC12781.1

Protein

Length

482 amino acids

Protein family membership

Fumarate lyase family (IPR000362)
- Adenylosuccinate lyase (IPR004769)

Domains and repeats

Domain
8 - 457
L-Aspartase-like (IPR008948)
Domain
43 - 304
Fumarate lyase, N-terminal (IPR022761)
373 - 457
Adenylosuccinate lyase C-terminal (IPR019468)

1 50 100 150 200 250 300 350 400 450 482

Detailed signature matches

IPR000362

Fumarate lyase family
1. PR00149 (FUMRATELYASE)
  
  147 - 165
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  241 - 268
  
  PRINTS
  PR00149 (FUMRATELYASE)
  
  284 - 300
  
  PRINTS
  PR00149 (FUMRATELYASE)
IPR004769

Adenylosuccinate lyase
1. TIGR00928
  
  10 - 456
  
  TIGRFAMs
  TIGR00928 (TIGR00928)
IPR008948

L-Aspartase-like
1. SSF48557 (L-asparta...)
  
  8 - 457
  
  SUPERFAMILY
  SSF48557 (L-aspartase-like)
IPR022761

Fumarate lyase, N-terminal
1. PF00206 (Lyase_1)
  
  43 - 304
  
  Pfam
  PF00206 (Lyase_1)
IPR019468

Adenylosuccinate lyase C-terminal
1. PF10397 (ADSL_C)
  
  374 - 456
  
  Pfam
  PF10397 (ADSL_C)
2. SM00998 (ADSL_C_2)
  
  373 - 457
  
  SMART
  SM00998 (ADSL_C_2)
IPR020557

Fumarate lyase, conserved site
1. PS00163 (FUMARATE_L...)
  
  284 - 293
  
  PROSITE patterns
  PS00163 (FUMARATE_LYASES)

no IPR

Unintegrated signatures

cd03302 (Adenylsucc...)

10 - 448

CDD
cd03302 (Adenylsuccinate_lyase_2)

Residue annotation

tetramer interface...

24S

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

25P

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

83D

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

92G

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

101I

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

102I

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

104L

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

105G

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

153F

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

154T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

155H

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

156F

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

157Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

158P

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

160Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

166K

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

167R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

170L

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

173Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

174E

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

180R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

181N

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

197T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

198T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

199G

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

200T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

203S

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

232Y

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

234V

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

235T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

242K

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

246D

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

253S

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

260K

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

264D

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

266R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

267L

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

269A

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

270N

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

292R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

293N

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

298E

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

302S

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

305R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

306H

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

308M

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

309V

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

312Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

313D

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

316M

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

317T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

321Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

322W

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

323F

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

324E

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

325R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

326T

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

327L

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

331A

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

332N

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

334R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

339E

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

379E

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

383M

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

386V

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

392R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

393Q

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

446I

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)

448R

tetramer interface
24S, 25P, 83D, 92G, 101I, 102I, 104L, 105G, 153F, 154T, 155H, 156F, 157Q, 158P, 160Q, 166K, 167R, 170L, 173Q, 174E, 180R, 181N, 197T, 198T, 199G, 200T, 203S, 232Y, 234V, 235T, 242K, 246D, 253S, 260K, 264D, 266R, 267L, 269A, 270N, 292R, 293N, 298E, 302S, 305R, 306H, 308M, 309V, 312Q, 313D, 316M, 317T, 321Q, 322W, 323F, 324E, 325R, 326T, 327L, 331A, 332N, 334R, 339E, 379E, 383M, 386V, 392R, 393Q, 446I, 448R
CDD
cd03302 (Adenylsuccinate_lyase_2)
active site cd03302

82H

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

103H

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

155H

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

237Q

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

291K

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

293N

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

298E

active site
82H, 103H, 155H, 237Q, 291K, 293N, 298E
CDD
cd03302 (Adenylsuccinate_lyase_2)

GO term prediction

Biological Process

GO:0009152 purine ribonucleotide biosynthetic process

Molecular Function

GO:0003824 catalytic activity
GO:0004018 N6-(1,2-dicarboxyethyl)AMP AMP-lyase (fumarate-forming) activity

Cellular Component

None predicted.

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Entry type

Status

Per-residue features